Alloantibodies causing haemolytic transfusion reactions or haemolytic disease in the fetus and newborn are dependent on the frequency with which alloantigens and alloantibodies occur.
Major Blood Group Phenotypes and their Frequencies (1–3) | |||||||
No | Blood Group System [Symbol] | Phenotype | % Frequency | No | Blood Group System [Symbol] | Phenotype | % Frequency |
001 |
ABO [ABO] |
A1 |
29.7 |
014 | Dombrock [DO]** | Do(a+b–) | 18 |
|
|
A2 |
9.3 |
Do(a–b+) | 33 | ||
|
|
B |
11.4 |
Do(a+b+) | 49 | ||
|
|
O |
46.1 |
Gy(a–) | Rare | ||
|
|
A1B |
2.3 |
015 | Colton | Co(a+b–) | 92.0 |
|
|
A2B |
1.2 |
Co(a–b+) | 0.2 | ||
002 |
MNS [MNS] |
MMSS |
6.0 |
Co(a+b+) | 7.8 | ||
|
|
MMss |
9.1 |
016 | Landsteiner-Wiener [LW]** | LW(a+b–) | 97 |
|
|
MMSs |
14.4 |
LW(a–b+) | Rare | ||
|
|
MNSS |
3.0 |
LW(a+b+) | 3 | ||
|
|
MNss |
23.3 |
017 | Chido/Rogers [CH/RG]** | Chido phenotype | |
|
|
MNSs |
22.7 |
CH/RG: 1,2,3 | 88.2 | ||
|
|
NNSS |
0.4 |
CH/RG: 1,–2,3 | 4.9 | ||
|
|
NNss |
15.6 |
CH/RG: 1,2,–3 | 3.1 | ||
|
|
NNSs |
5.5 |
CH/RG: –1,–2,–3 | 3.8 | ||
003 |
P [P] |
P1+ |
74.8 |
CH/RG: –1,2,-3 | Rare | ||
|
|
P1– |
25.2 |
CH/RG: 1,–2,–3 | Rare | ||
004 |
Rh [RH] |
See Rhesus phenotypes |
Rodgers phenotype | ||||
005 |
Lutheran [LU] |
Lu(a+b–) |
0.2 |
CH/RG: 11,12 | 95 | ||
|
|
Lu(a–b+) |
92.3 |
CH/RG: 11,–12 | 3 | ||
|
|
Lu(a+b+) |
7.5 |
CH/RG: –11,–12 | 2 | ||
|
|
Lu(a–b–) |
Rare |
018 | H [H] | H | High incidence |
006 |
Kell [KEL] |
K– k+ |
90.9 |
019 | Kx [XK] | Kx | High incidence |
|
|
K+ k– |
0.4 |
020 | Gerbich [GE]** | Ge:2,3,4 | >99.9 |
|
|
K+ k+ |
8.7 |
Ge:–2,3,4 (Yus type) | Rare | ||
|
|
Kp(a+b–) |
<0 .1="" p=""> 0> | Ge:–2,–3,4 (Gerbich type) | Rare | ||
|
|
Kp(a–b+) |
97.8 |
Ge:–2,–3,–4 (Leach) | Rare | ||
|
|
Kp(a+b+) |
2.2 |
021 | Cromer [CROM] | Cra, Tca, Dra, Esa | High Incidence |
007 |
Lewis [LE] |
Le(a+b–) |
22.4 |
Tcb, Tcc, WESa | Low incidence | ||
|
|
Le(a–b+) |
72.3 |
022 | Knops [KN]** | Kn(a+b–) | 94.5 |
|
|
Le(a–b–) |
5.3 |
Kn(a–b+) | 1 | ||
008 |
Duffy [FY] |
Fy(a+b–) |
19.7 |
Kn(a+b+) | 4.5 | ||
|
|
Fy(a–b+) |
32.7 |
McC(a+) | 98 | ||
|
|
Fy(a+b+) |
47.6 |
Sl(a+) | 98 | ||
009 |
Kidd [JK] |
Jk(a+b–) |
26.3 |
Yk(a+) | 92 | ||
|
|
Jk(a–b+) |
23.6 |
023 | Indian [IN]** | In(a+b–) | Rare |
|
|
Jk(a+b+) |
50.1 |
In(a–b+) | 99.9 | ||
010 |
Diego [DI]** |
Di(a+b–) |
<0 .01="" p=""> 0> | In(a+b+) | <0 .1="" td=""> 0> | ||
|
|
Di(a-b+) |
>99.9 |
024 | Ok [OK]** | Ok(a+) | 100 |
|
|
Di(a+b+) |
<0 .1="" p=""> 0> | Ok(a–) | Rare | ||
|
|
Wr(a+) |
<0 .1="" p=""> 0> | 025 | Raph [RAPH] | MER2 | |
|
|
Wr(b+) |
High incidence |
026 | John Milton Hagen [JMH] | JMH | High incidence |
011 |
Yt [YT]** |
Yt(a+b–) |
91.9 |
027 | I [I] | I | High incidence |
|
|
Yt(a–b+) |
0.3 |
028 | Globoside [GLOB] | P | High incidence |
|
|
Yt(a+b+) |
7.8 |
029 | Gill [GIL] | GIL | High incidence |
012 |
Xg [XG]** |
Xg(a+) |
Male 65.6 Female 88.7 |
Antigen Collections** |
Csa / Csb Vel / ABTI |
95 / 34 Both >99 |
|
|
|
Xg(a–) |
Male 34.4 Female 11.3 |
Low incidence antigens (700 series) | By, Chra, Bi, Bxa, Pta, Rea etc. | <1 td=""> 1> | |
013 |
Scianna [SC]** |
Sc:1,–2 |
99 |
High incidence antigens (901 series) | Lan, Ata, Jra, AnWj, Sda, Duclos etc. | >90 | |
|
|
Sc:–1,2 |
Rare |
||||
|
|
Sc:1,2 |
1 |
||||
|
|
Sc:1,–2,Rd+ |
Rare |
||||
|
|
Sc:1,2,Rd+ |
Rare |
||||
Note: Unless indicated, frequencies are based on blood group statistics of Australian blood donors; ** Frequency is based on Caucasian population. |